BDBM50565841 CHEMBL4795253

SMILES CC(=O)c1ccc(cc1)S(=O)(=O)N(c1ccc2CCCN(c2c1)S(C)(=O)=O)S(=O)(=O)c1ccc(cc1)C(C)=O

InChI Key InChIKey=JFEVMHYDPVBRGT-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50565841   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataIC50:  7.81E+3nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataKd:  1.72E+4nMAssay Description:Binding affinity to biotinylated human recombinant NLRP3 NACHT domain by biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataKd:  8.80nMAssay Description:Binding affinity to biotinylated human recombinant NLRP3 PYD domain by biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed