BDBM50567176 CHEMBL4856826

SMILES C=CC(=O)N1CCN(c2cc(C(=O)N[C@H](C)CN(C)C)nc3c2CCN(c2c(Cl)c(C)cc4[nH]ncc24)C3)C[C@@H]1CC#N

InChI Key InChIKey=SRUSZDKVYRGESJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50567176   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50567176BDBM50567176(CHEMBL4856826)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of biotinylated KRAS G12C mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for 60 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed