BDBM50567694 CHEMBL4858994

SMILES ONC(=O)c1ccc(CN2CCCSc3ccccc23)cc1

InChI Key InChIKey=CHULCWZHWRQEQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50567694   

TargetHistone deacetylase 6(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50567694(CHEMBL4858994)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HDAC6 preincubated for 15 mins followed by substrate addition by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50567694(CHEMBL4858994)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50567694(CHEMBL4858994)
Affinity DataIC50: 254nMAssay Description:Inhibition of human HDAC1 preincubated for 15 mins followed by substrate addition by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50567694(CHEMBL4858994)
Affinity DataIC50: 254nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by compound addition and measured after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed