BDBM50567818 CHEMBL4863979

SMILES CCCC1CN(CCN1)C(=O)c1cc(-c2nc(cs2)-c2ccc(Cl)cc2)c(=O)n(c1C=C(C)C)-c1c(CC)cccc1CC

InChI Key InChIKey=NWZXZWDVOUULNQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50567818   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567818(CHEMBL4863979)
Affinity DataIC50: 82nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567818(CHEMBL4863979)
Affinity DataIC50: 130nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed