BDBM50568720 CHEMBL4862321

SMILES Cc1c(c(c([nH]1)C(=O)Nc2nc3cc(c(cc3s2)C(=O)O)O)Cl)Cl

InChI Key InChIKey=SEAMOYQPPFJZJR-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568720   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568720(CHEMBL4862321 | US12258342, Example 13)
Affinity DataIC50: 5nMAssay Description:First, the plates were rehydrated with buffer (20 mM Tris-HCl with pH 7.6, 0.01% w/v BSA, 0.05% v/v Tween 20, 137 mM NaCl) and the biotinylated oligo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568720(CHEMBL4862321 | US12258342, Example 13)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568720(CHEMBL4862321 | US12258342, Example 13)
Affinity DataIC50: 61nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed