BDBM50568955 CHEMBL4853833

SMILES COc1cc2ncnc(Nc3cccc(c3)C(F)(F)F)c2cc1OCCCCC(=O)Nc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=BAZHYSJCJCDBSD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50568955   

TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50568955(CHEMBL4853833)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR T790M mutant (669 to 1210 residues) expressed in baculovirus expression system using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50568955(CHEMBL4853833)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus expression system using peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50568955(CHEMBL4853833)
Affinity DataIC50: 115nMAssay Description:Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50568955(CHEMBL4853833)
Affinity DataIC50: 278nMAssay Description:Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed