BDBM50569201 CHEMBL4858564

SMILES Cc1c(CN2CCN(CC2)C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=FEAZPCVGCIRWDR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50569201   

TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of PARP2 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PARP1 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 40 mins by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 2 hrs by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 25nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 50nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 53nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569201(CHEMBL4858564)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed