BDBM50569663 CHEMBL4870155

SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2C(C)(F)F)n1

InChI Key InChIKey=QVBLNESWDRSUKK-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569663   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50569663(CHEMBL4870155)Copy SMILESCopy InChI

Affinity DataIC50: 0.0270nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50569663(CHEMBL4870155)Copy SMILESCopy InChI

Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human HPK1 catalytic domain (1 to 346 residues) using His-tagged SLP76 as substrate assessed as reduction in substrate phosphorylation ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/18/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL