BDBM50569836 CHEMBL4850926

SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc(cc1)C(=O)NO)c1nnc(C)n-21)c1ccc(Cl)cc1

InChI Key InChIKey=JBPWXWQIGDWQHR-UHFFFAOYSA-N

Data  31 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50569836   

TargetBromodomain testis-specific protein(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRDT-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD4-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRDT-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRDT BD2 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRDT BD1 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 15 mins by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD4-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD2-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD2-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD3-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 15 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 (unknown origin) BD1 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant BRD3-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 34nMAssay Description:Inhibition of HDAC6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 38nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) incubated for 180 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 39nMAssay Description:Inhibition of HDAC3 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 52nMAssay Description:Inhibition of HDAC2 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 78nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) incubated for 180 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataKd:  90nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 133nMAssay Description:Inhibition of recombinant BRD3 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 192nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluoro-Substrate Peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 316nMAssay Description:Inhibition of recombinant BRD2 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of BRDT BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed