BDBM50569895 CHEMBL4862887

SMILES CCOc1cc2C(Cc3c[nH]c4ccccc34)N(CCc2cc1OC)C=O

InChI Key InChIKey=ZGTKBCRXUMJCPQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50569895   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50569895(CHEMBL4862887 | US12145923, Compound C10)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human PDE4D (83 to 416 residues) expressed in Escherichia coli BL21 (DE3) assessed as hydrolysis of [3H]-cAMP measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50569895(CHEMBL4862887 | US12145923, Compound C10)
Affinity DataIC50: 140nMAssay Description:Inhibition of PDE4 (unknown origin) by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50569895(CHEMBL4862887 | US12145923, Compound C10)
Affinity DataIC50: 8.00E+4nMAssay Description:The scintillation Proximity Assay (SPA) method was used to determine the inhibitory effect of compounds on the activity of PDE4D catalytic domain. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
US Patent