BDBM50570254 CHEMBL4865865
SMILES CN1CCC(CC1)Oc1ccc(cc1)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
InChI Key InChIKey=IZKSMIBPGSWAMO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50570254
Affinity DataKi: 8.40nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
Affinity DataKi: 9.90E+3nMAssay Description:Binding affinity to glucocorticoid receptor in human IM-9 cells assessed as inhibition constant incubated for 6 hrs by Cheng-Prusoff equation analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Antagonist activity at wild type androgen receptor in castration-resistant human LNCaP cells assessed as inhibition of R1881-stimulated receptor tran...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells assessed as inhibition of R1881-stimulated receptor transcri...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dexamethasone from glucocorticoid receptor in human IM-9 cells incubated for 6 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]methyltrienolone from wild-type androgen receptor in human LNCaP cells incubated for 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Antagonist activity at VP16-AR wild-type (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs in presenc...More data for this Ligand-Target Pair