BDBM50570255 CHEMBL4869652

SMILES COc1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCN(C)CC3)cc2)C2(CCC2)C1=O

InChI Key InChIKey=JQULNFLHCKLUKJ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50570255   

TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataIC50: 214nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataIC50: 302nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataEC50:  649nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed