BDBM50570956 CHEMBL4869882

SMILES Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC1CC1

InChI Key InChIKey=ZAEWPVUVQVUGEE-OAQYLSRUSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570956   

TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570956(CHEMBL4869882)
Affinity DataIC50:  27nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570956(CHEMBL4869882)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed