BDBM50572670 CHEMBL4872371

SMILES O=C(NCc1ccc2[nH]ccc2c1)N1CC(COc2ccc(C(F)(F)F)cc2)C1

InChI Key InChIKey=CREAVHWWSWYHAQ-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572670   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Gedeon Richter

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572670BDBM50572670(CHEMBL4872371)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Gedeon Richter

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572670BDBM50572670(CHEMBL4872371)
Affinity DataEC50:  590nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in HEK293 cells assessed as increase in peak current amplitude measured after 6 to 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50572670BDBM50572670(CHEMBL4872371)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells measured after 7 to 10 mins at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed