BDBM50572786 CHEMBL4876215

SMILES CC(=O)N1CCC(N2C[C@H]3C[C@@H](C2)c2ccc(-c4ccccc4CN4CCOCC4)c(=O)n2C3)CC1

InChI Key InChIKey=WLGRGOGJTIXJGZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572786   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572786BDBM50572786(CHEMBL4876215)
Affinity DataIC50: 890nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572786BDBM50572786(CHEMBL4876215)
Affinity DataIC50: 8.00E+5nMAssay Description:Inhibition of human NSD2 SET domain (948 to 1239 residues) expressed in Escherichia coli BL21 assessed as decrease in HMTase activity on H3K36 using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572786BDBM50572786(CHEMBL4876215)
Affinity DataIC50: 8.90E+5nMAssay Description:Inhibition of recombinant NSD2-SET (unknown origin) expressed in Escherichia coli BL21 using H3K36 as substrate preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed