BDBM50572813 CHEMBL4862431

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)COC1)c1c(F)cc(OCCN2CC(CF)C2)cc1F

InChI Key InChIKey=JJJTVYOYFYQVHM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572813   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572813(CHEMBL4862431 | US20250114338, Example 136)
Affinity DataEC50:  0.114nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572813(CHEMBL4862431 | US20250114338, Example 136)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed