BDBM50573312 CHEMBL4877122

SMILES COC(=O)c1cccc(COc2c(oc3ccccc3c2=O)-c2ccc(OCCOCCn3cc(CN(C)Cc4ccccc4)nn3)cc2)c1

InChI Key InChIKey=BFBROVVYIPVQJI-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50573312   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50:  15nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MCF7/MX100 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50:  681nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50:  17nMAssay Description:Inhibition of BCRP (unknown origin) expressed in human HEK293/R2 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50:  644nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573312(CHEMBL4877122)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed