BDBM50573432 CHEMBL4854390

SMILES Cc1ccnc(C(C)C)c1-n1c(=O)nc(N2C[C@@H](C)N(C(=O)[C@H]3CO3)C[C@@H]2C)c2cc(Cl)c(-c3c(N)cccc3F)nc21

InChI Key InChIKey=NBLPZTHALLWALD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50573432   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573432BDBM50573432(CHEMBL4854390)
Affinity DataIC50: 15nMAssay Description:Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573432BDBM50573432(CHEMBL4854390)
Affinity DataIC50: 560nMAssay Description:Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed