BDBM50573688 CHEMBL4127773

SMILES COc1ncccc1-c1cnn2ccc(nc12)N1CCN(CC1)C(=O)OC(C)C

InChI Key InChIKey=GOOYSJIWTIHOGW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50573688   

TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant AAK1 expressed in human HEK293F cells co-expressed with AP-2 assessed as reduction in AP-2 phosphorylation by western blott...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human GST-Xa-tagged-AAK1 (30 to 330 residues) expressed in baculovirus expression system using (5 -FAM)-Aha-KEEQSQITSQVTGQI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant AAK1 (unknown origin) expressed in baculovirus assessed as reduction in AP-2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 10nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBMP-2-inducible protein kinase [38-345,K320A,K321A](Human)
Satellos Bioscience

US Patent
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 33.3nMAssay Description:This example describes one illustrative method for determining the IC50 of the compounds of the present invention against BIKE (amino acids S38-E345)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-G-associated kinase [25-335](Human)
Satellos Bioscience

US Patent
LigandPNGBDBM50573688(CHEMBL4127773 | US20250270222, Compound LP-935509)
Affinity DataIC50: 720nMAssay Description:This example describes one illustrative method for determining the IC50 of the compounds of the present invention against GAK (amino acids Q25-N335)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent