BDBM50573710 CHEMBL4847264

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1N

InChI Key InChIKey=LWZHQZHKOWYTJH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50573710   

TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of wild type EGFR L858R mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of wild type EGFR C797S mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type EGFR Del E746/A750 mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of wild type EGFR L858R/T790M mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type EGFR (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by mobility shift...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 119nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50573710(CHEMBL4847264)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed