BDBM50574072 CHEMBL4869330

SMILES OC(=O)CCNC(=S)NCCCNc1nc(CCc2c[nH]c3ccccc23)ncc1C(O)=O

InChI Key InChIKey=XZKJHCUXRYHRMJ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50574072   

LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate in presence of NAD+ by fluorescence based an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 4.44E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate in presence of NAD+ by fluorescence based an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 7.62E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 50 uM NAD+...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 200 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 100 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 800 uM NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 11 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 33 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 5.89E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 100 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 7.76E+4nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using 300 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT3 (unknown origin) using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using Ac-Glu-Thr-Asp-Lys(Dec)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50574072(CHEMBL4869330)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT6 (unknown origin) using Ac-Ile-Arg-Ile-Lys(Su)-AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed