BDBM50574624 CHEMBL4848234

SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1Cl

InChI Key InChIKey=CLOCGENGHUXYHT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50574624   

TargetEpidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50574624(CHEMBL4848234)
Affinity DataIC50: 117nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50574624(CHEMBL4848234)
Affinity DataIC50: 169nMAssay Description:Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed