BDBM50574629 CHEMBL4870560

SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(OCCCN3CCOCC3)cc2)ncc1Cl

InChI Key InChIKey=PEQGAZZCACDPPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50574629   

TargetEpidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50574629(CHEMBL4870560)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50574629(CHEMBL4870560)
Affinity DataIC50: 65nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed