BDBM50576518 CHEMBL4848638

SMILES CC(=O)c1cc2c3c(c(C)cc2oc1=O)O[C@](C)(CC/C=C(\C)CC/C=C(\C)CCC=C(CO)CO)CC3

InChI Key InChIKey=JLNAQSXKMMQKIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576518   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576518BDBM50576518(CHEMBL4848638)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by arachidonic acid addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576518BDBM50576518(CHEMBL4848638)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of AA and A23187 and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed