BDBM50576892 CHEMBL4859892

SMILES CC(C)n1cnnc1-c1ccc2[nH]nc(-c3ccc(N4CCOCC4)c(c3)-n3cnc(c3)C3CC3)c2c1

InChI Key InChIKey=SKCKODMQNKHQBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576892   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50576892(CHEMBL4859892)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full length recombinant ASK1 using STK-Substrate-3 biotin as substrate in presence of ATP measured after 2 hrs by HTRP kinase ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50576892(CHEMBL4859892)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of ASK1 in human HEK293 cells transfected with AP1 assessed as inhibition of AP1-induced firefly luciferase activity preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed