BDBM50576895 CHEMBL4878227

SMILES COc1cc(cc(c1)-n1cnc(c1)C1CC1)-c1n[nH]c2ccc(cc12)-c1nncn1C(C)C

InChI Key InChIKey=ZENAXMDBEGZACM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576895   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50576895(CHEMBL4878227)
Affinity DataIC50: 49nMAssay Description:Inhibition of human full length recombinant ASK1 using STK-Substrate-3 biotin as substrate in presence of ATP measured after 2 hrs by HTRP kinase ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50576895(CHEMBL4878227)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of ASK1 in human HEK293 cells transfected with AP1 assessed as inhibition of AP1-induced firefly luciferase activity preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed