BDBM50578621 CHEMBL4853212

SMILES CC1(CN(CC[C@@]12C(=O)NC(=O)N2)c3cc(cc4n3cnc4)C(F)(F)F)C

InChI Key InChIKey=UBMTZODMRPHSBC-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50578621   

TargetIndoleamine 2,3-dioxygenase 1(Mouse)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578621(CHEMBL4853212)
Affinity DataIC50: 23nMAssay Description:Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578621(CHEMBL4853212)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human His-tagged IDO1 (Ala2 to Gly403 residues) expressed in Escherichia coli using tryptophan as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578621(CHEMBL4853212)
Affinity DataIC50: 26nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578621(CHEMBL4853212)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578621(CHEMBL4853212)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed