BDBM50578649 CHEMBL4866113

SMILES [H][C@@]12C[C@H](C[C@]1([H])[C@H]2C(CC)NC(=O)c1ccc(Cl)cc1)n1cnc2cc(F)ccc12

InChI Key InChIKey=MYCSOYFHSBECSR-DNCGZWEUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50578649   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578649(CHEMBL4866113)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578649(CHEMBL4866113)
Affinity DataIC50:  180nMAssay Description:Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578649(CHEMBL4866113)
Affinity DataIC50:  23nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated mouse Panc02 cells incubated for 48 hrs by RFMS methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Texas

Curated by ChEMBL
LigandPNGBDBM50578649(CHEMBL4866113)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LCMS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed