BDBM50579534 CHEMBL4877598

SMILES ONC(=O)CCCO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)N(CC#C)c2ccccc12

InChI Key InChIKey=KHLNXOSMRTVVRE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50579534   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human CDK6 (1 to 326 end residues)/N-terminal GST-fusion tagged CyclinD3 (1 to 292 residues) expressed in baculovirus expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human CDK2 (1 to 298 end residues)/N-terminal GST-tagged CyclinA2 (1 to 432 residues) expressed in baculovirus expression s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human CDK4 (1 to 303 residues)/N-terminal GST-fusion tagged CyclinD3 (1 to 292 residues) expressed in baculovirus expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of recombiant human HDAC6 using fluorogenic HDAC substrate 3 measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human HDAC11 measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HDAC7 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC4 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50579534(CHEMBL4877598)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC2 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed