BDBM50579546 CHEMBL4849014

SMILES COc1ncc(F)cc1C(=O)Nc1cccc(n1)-c1nncn1[C@@H](C)C(F)(F)F

InChI Key InChIKey=MXOCTLMVBIGSKH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50579546   

LigandPNGBDBM50579546(CHEMBL4849014)
Affinity DataIC50: 7nMAssay Description:Inhibition of ASK1 (unknown origin) using myelin basic protein as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50579546(CHEMBL4849014)
Affinity DataIC50: 25nMAssay Description:Inhibition of full-length human ASK1 expressed in HEK293T cells assessed as reduction in autophosphorylation of ASK1 at T383 residue incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50579546(CHEMBL4849014)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50579546(CHEMBL4849014)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50579546(CHEMBL4849014)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed