BDBM50579562 CHEMBL4862258

SMILES COc1nn(CC(F)(F)F)cc1C(=O)Nc1cccc(n1)-c1nncn1[C@@H](C)C(F)(F)F

InChI Key InChIKey=DXWUXPKKSJLAJZ-VIFPVBQESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579562   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50579562(CHEMBL4862258)
Affinity DataIC50:  36nMAssay Description:Inhibition of full-length human ASK1 expressed in HEK293T cells assessed as reduction in autophosphorylation of ASK1 at T383 residue incubated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50579562(CHEMBL4862258)
Affinity DataIC50:  3nMAssay Description:Inhibition of ASK1 (unknown origin) using myelin basic protein as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed