BDBM50579563 CHEMBL4850048

SMILES COCCn1cc(C(=O)Nc2cccc(n2)-c2nncn2[C@@H](C)C(F)(F)F)c(OC)n1

InChI Key InChIKey=MKFPXXSISGYYFB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579563   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50579563(CHEMBL4850048)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of ASK1 (unknown origin) using myelin basic protein as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/25/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50579563(CHEMBL4850048)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Inhibition of full-length human ASK1 expressed in HEK293T cells assessed as reduction in autophosphorylation of ASK1 at T383 residue incubated for 1 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/25/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL