BDBM50579719 CHEMBL5075213

SMILES COc1cc(ccc1NC(=O)c1cccc(n1)-c1cc[nH]n1)N1CCN(CCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)CC1

InChI Key InChIKey=WAOZMJFYNREQLU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579719   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579719(CHEMBL5075213)
Affinity DataIC50: 80nMAssay Description:Inhibition of truncated human N-terminal GST-fusion tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using FAM-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579719(CHEMBL5075213)
Affinity DataIC50: 368nMAssay Description:Inhibition of full length human N-terminal GST-fusion tagged IRAK4 expressed in baculovirus expression system using FAM-labelled peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579719(CHEMBL5075213)
Affinity DataIC50: 1.65E+3nMAssay Description:Displacement of 5-FAM-labelled DEALA-HypYIPMDDDFQLRSF peptide from VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed