BDBM50581627 CHEMBL5085549::US20240158414, Example 130

SMILES C[C@H](Oc1cc(-c2cn(C)c(n2)C(C)(C)O)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F

InChI Key InChIKey=AHTZDUDQEMHWHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50581627   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM50581627(CHEMBL5085549 | US20240158414, Example 130)
Affinity DataIC50: 0.190nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM50581627(CHEMBL5085549 | US20240158414, Example 130)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed