BDBM50582389 CHEMBL5089835

SMILES CCN(c1cc(-c2ccc(CN3CCN(CCCCCCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1

InChI Key InChIKey=LONVYJSHGSZBQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582389   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582389BDBM50582389(CHEMBL5089835)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal His-tagged EZH2 in human PRC2 complex (2 to end residues) expressed in Sf9 cells using [3H]-SAM as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582389BDBM50582389(CHEMBL5089835)
Affinity DataIC50: 5nMAssay Description:Inhibition of EZH2 methyltransferase activity in human PA-1 cells assessed as reduction in H3K27me3 level measured after 4 days by Western blot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582389BDBM50582389(CHEMBL5089835)
Affinity DataIC50: 179nMAssay Description:Inhibition of recombinant full length human N-terminal FLAG-tagged EZH1 in PRC2 complex expressed in baculovirus system using SAM as substrate preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed