BDBM50582559 CHEMBL5093894

SMILES CN1CCN(CC1)[C@H]1CC(F)(F)c2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)ccc12

InChI Key InChIKey=BPLVEFPXYUJTQJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50582559   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human c-SRC using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human KDR/VEGFR2 using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human LYN using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDGFRa using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGFR1 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGFR2 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 52nMAssay Description:Inhibition of FGFR3 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 124nMAssay Description:Inhibition of FGFR4 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50582559(CHEMBL5093894)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed