BDBM50583996 CHEMBL4554938

SMILES CN1c2ccsc2C(=O)N(c3c1nc(nc3)Nc4ccc(cc4)S(=O)(=O)N)C

InChI Key InChIKey=YRDHKIFCGOZTGD-UHFFFAOYSA-N

Data  3 IC50

PDB links: 4 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50583996   

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of TYK2 JH1domain-catalytic (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to PIK3CG (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  5nMAssay Description:Binding affinity to TYK2 JH1domain-catalytic (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of MST1 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  11nMAssay Description:Binding affinity to MST2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 12nMAssay Description:Inhibition of phosphorylated ABL1 Q252H mutant (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

TargetAurora kinase A(Human)TBA
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  13nMAssay Description:Binding affinity to AURKA (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  16nMAssay Description:Binding affinity to MST4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  17nMAssay Description:Binding affinity to MST1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 18nMAssay Description:Inhibition of phosphorylated ABL1 M351T mutant (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 18nMAssay Description:Inhibition of MST2 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  18nMAssay Description:Binding affinity to MST3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  19nMAssay Description:Binding affinity to MAP3K2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

TargetAurora kinase B(Human)TBA
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 19nMAssay Description:Inhibition of AURKB (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

TargetAurora kinase A(Human)TBA
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 19nMAssay Description:Inhibition of AURKA (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  22nMAssay Description:Binding affinity to JAK1 JH2domain-pseudokinase (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  24nMAssay Description:Binding affinity to phosphorylated ABL1 Q252H mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  25nMAssay Description:Binding affinity to DCAMKL1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 27nMAssay Description:Inhibition of MST4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  27nMAssay Description:Binding affinity to MAP3K3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 28nMAssay Description:Inhibition of DCAMKL1 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant His-tagged full-length MST2 (unknown origin) expressing in Escherichia coli assessed as MOB1a phosphorylation level incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  34nMAssay Description:Binding affinity to PIK3CA H1047L mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  34nMAssay Description:Binding affinity to PIP5K2C (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  35nMAssay Description:Binding affinity to ULK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 38nMAssay Description:Inhibition of PIK3CG (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant His-tagged full-length MST2 (unknown origin) expressing in Escherichia coli assessed as GST-tagged MOB1a phosphorylation le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 38nMAssay Description:Inhibition of MAP3K3 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 38nMAssay Description:Inhibition of Flag-tagged full-length MST2 (unknown origin) transfected in HEK293T cells assessed as MOB1a phosphorylation level incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant His-tagged full-length MST2 (unknown origin) expressing in Escherichia coli assessed as MOB1 phosphorylation level incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK1 JH2domain-pseudokinase (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

TargetAurora kinase B(Human)TBA
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  40nMAssay Description:Binding affinity to AURKB (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 42nMAssay Description:Inhibition of ULK2 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  42nMAssay Description:Binding affinity to phosphorylated ABL1 M351T mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 45nMAssay Description:Inhibition of MST3 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 71nMAssay Description:Inhibition of Flag-tagged full-length MST1 (unknown origin) transfected in HEK293T cells assessed as MOB1a phosphorylation level incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant His-tagged full-length MST1 (unknown origin) expressing in Escherichia coli assessed as MOB1 phosphorylation level incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  77nMAssay Description:Binding affinity to PIP5K1C (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 80nMAssay Description:Inhibition of MAP3K2 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  100nMAssay Description:Binding affinity to TAOK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 104nMAssay Description:Inhibition of recombinant full length N-terminal GST -tagged human MST1 expressed in baculovirus infected Sf9 insect cells using KKSRGDYMTMQIG as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 134nMAssay Description:Inhibition of TAOK2 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  140nMAssay Description:Binding affinity to RIPK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 162nMAssay Description:Inhibition of MST1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 164nMAssay Description:Inhibition of recombinant His-tagged full-length MST1 (unknown origin) expressing in Escherichia coli assessed as MOB1a phosphorylation level incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 165nMAssay Description:Inhibition of TAOK1 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 177nMAssay Description:Inhibition of recombinant His-tagged full-length MST2 (unknown origin) expressing in Escherichia coli assessed as MOB1a phosphorylation level incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  180nMAssay Description:Binding affinity to TAOK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 254nMAssay Description:Inhibition of TAOK3 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details

LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant His-tagged full-length MST2 (unknown origin) expressing in Escherichia coli assessed as MOB1a phosphorylation level incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PDB3D3D Structure (crystal)
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