BDBM50585312 CHEMBL5093794

SMILES COC(=O)N(C)CCN(C)c1cc(OC)c(Nc2nccc(Nc3ccn(C)n3)n2)cc1NC(=O)C=C

InChI Key InChIKey=PCOWIWPGWAPOBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50585312   

TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585312(CHEMBL5093794)
Affinity DataIC50: 288nMAssay Description:Inhibition of EGFR del19 (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585312(CHEMBL5093794)
Affinity DataIC50: 502nMAssay Description:Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585312(CHEMBL5093794)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed