BDBM50585388 CHEMBL5087737

SMILES Oc1cc(-c2ncc3c(nc(OCC45CCCN4CCCC5)nc3c2F)N2CC3CCC(C2)N3)c2ccccc2c1

InChI Key InChIKey=ZXLXXBNGGWBUJO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50585388   

TargetGTPase KRas(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585388(CHEMBL5087737)
Affinity DataIC50: 650nMAssay Description:Inhibition of KRAS G12D mutant in human AGS cells assessed as reduction in ERK phosphorylation measured after 3 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed