BDBM50586153 CHEMBL5078476

SMILES Cc1cc(C)n(C)c(=O)c1CN1CCc2c(Cl)cc(-c3c(C)noc3C)c(Cl)c2C1=O

InChI Key InChIKey=GWDVHMHVEQPHSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586153   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Tri-Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586153BDBM50586153(CHEMBL5078476)
Affinity DataIC50: 14nMAssay Description:Inhibition of EZH2 (unknown origin) using 3H-SAM as substrate incubated for 1 hour by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Tri-Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586153BDBM50586153(CHEMBL5078476)
Affinity DataIC50: 580nMAssay Description:Inhibition of EZH2 in HEK293T cells assessed as H3K27me3 levels incubated for 48 hrs by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed