BDBM50587104 CHEMBL5069975::US20240043470, Compound 2-02-B

SMILES c1ccc(cc1)[C@H]2CCCN2C(=O)C[C@H]3C(=O)N[C@@H](Cc4ccc(cc4)Oc5cccc(c5)CCC(=O)N3)C(=O)NCc6ccccc6F

InChI Key InChIKey=GSMYFOQUVZHNEZ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587104   

TargetProteasome subunit beta type-8(Human)
Cornell University

US Patent
LigandPNGBDBM50587104(CHEMBL5069975 | US20240043470, Compound 2-02-B)
Affinity DataIC50: 6.75E+3nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50587104(CHEMBL5069975 | US20240043470, Compound 2-02-B)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5c subunit using Suc-LLVY-AMC as substrate measured over 1.5 to 2 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50587104(CHEMBL5069975 | US20240043470, Compound 2-02-B)
Affinity DataIC50: 1.00E+5nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetProteasome subunit beta type-8(Human)
Cornell University

US Patent
LigandPNGBDBM50587104(CHEMBL5069975 | US20240043470, Compound 2-02-B)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate measured over 1.5 to 2 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed