BDBM50587891 CHEMBL5181237::US11814388, Compound 4

SMILES Brc1cccc(Nc2ncnc3[nH]ccc23)c1

InChI Key InChIKey=CGTJZAKCIVQOPI-UHFFFAOYSA-N

Data  7 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50587891   

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) preincubated for 60 mins in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) using Poly(Glu, Tyr) as substrate incubated for 45 mins in presence of ATP by ADP-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated for 45 mins in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  50nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  50nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  50nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  67nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  67nMAssay Description:Binding affinity to DNA-tagged EGFR (unknown origin) expressed in bacterial system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  67nMAssay Description:Binding affinity to wild type human EGFR partial length (R669 to V1011 residues) expressed in bacterial expression system assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  67nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 449nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of AURKA (unknown origin) in presence of ATP by ADP-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide as substrate incubated for 50 mins in the presence of ATP by ADP-Glo reagent based luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of AURKA (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated for 45 mins in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  3.40E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to DNA-tagged Aurora A (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  3.40E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of EGFR (unknown origin) using Poly(Gly,Tyr) as substrate incubated for 45 mins in the presence of ATP by ADP-Glo reagent based luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) preincubated for 60 mins in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  4.80E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  4.80E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to DNA-tagged Aurora B (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4 | US1241017...)
Affinity DataIC50: 1.19E+5nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed