BDBM50588525 CHEMBL5177956
SMILES COc1ccc(cc1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1
InChI Key InChIKey=WHDQELXDNKHASW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50588525
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 30 mins in presence of NADPH by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 60 mins in presence of NADPH by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 60 mins in presence of NADPH by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in presence of NADPH by HPLC analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38delta (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataKd: 21nMAssay Description:Binding affinity to human recombinant STAT3 expressed in Escherichia coli BL21 by MST assayMore data for this Ligand-Target Pair