BDBM50590377 CHEMBL5196492

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=SZAYCVHJDOWSNY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50590377   

TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590377(CHEMBL5196492)
Affinity DataIC50: 4nMAssay Description:Inhibition of EZH2 A677G mutant (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590377(CHEMBL5196492)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wildtype EZH2 (unknown origin) by AlphaLISA methyltransferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590377(CHEMBL5196492)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590377(CHEMBL5196492)
Affinity DataIC50: 15nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590377(CHEMBL5196492)
Affinity DataIC50: 15nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed