BDBM50590761 CHEMBL5207789

SMILES Cc1ccc(CNc2cc(cc3[nH]ncc23)C(F)(F)F)c(c1)[N+](O)=O

InChI Key InChIKey=OJGNTEVGALHBAH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50590761   

TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50590761(CHEMBL5207789)
Affinity DataIC50: 60nMAssay Description:Inhibition of TDO in HEK293-A cells transfected with pCMV-TDO2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50590761(CHEMBL5207789)
Affinity DataIC50: 620nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human TDO (19 to 388 residues) expressed in Escherichia coli Transetta (DE3) using L-tryptophan as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50590761(CHEMBL5207789)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human IDO1 (12 to 403 residues) expressed in Escherichia coli Transetta (DE3) using L-tryptophan as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed