BDBM50590826 CHEMBL5195375

SMILES C[C@@H](Nc1ccn2ncc(-c3cnn(c3)C3CCOCC3)c2n1)c1cc(F)ccc1F

InChI Key InChIKey=NMLNFZDWCDBUBQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50590826   

TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50590826(CHEMBL5195375)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type TRKA (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50590826(CHEMBL5195375)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TRKA F589L mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50590826(CHEMBL5195375)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed