BDBM50591112 CHEMBL5189365

SMILES CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(CC1)c1ncc(cn1)C(=O)NO)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=DTYUAFQIQYXAKJ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50591112   

TargetHistone-lysine N-methyltransferase EZH2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 59nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged/N-terminal Strep2 tagged human HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells incubated for 2 hrs by Multimode ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 120nMAssay Description:Inhibition of HDAC1 (unknown origin) preincubated for 5 mins followed by substrate addition and measured after 30 mins by multimode microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 700nMAssay Description:Inhibition of HDAC6 (unknown origin) preincubated for 5 mins followed by substrate addition and measured after 30 mins by multimode microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 700nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 780nMAssay Description:Inhibition of full length recombinant human C-terminal GST-fusion-tagged human HDAC2 (1 to 488 residues) expressed in insect cells using RHK-K(Ac)-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 2 hrs by Multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of N-terminal Strep2-tagged recombinant His-tagged human HDAC11 (1 to 347 residues) using trifluoroacetyl lysine as substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of recombinant C-terminal his fusion-tagged human HDAC5 (656 to 1122 residues) expressed in baculovirus expression system using trifluoroa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC4 (627 to 1084 residues) expressed in baculovirus expression system using trifluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 7.05E+3nMAssay Description:Inhibition of HDAC9 (unknown origin) incubated for 2 hrs by Multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591112(CHEMBL5189365)
Affinity DataIC50: 8.19E+3nMAssay Description:Inhibition of N-terminal GST-fusion tagged recombinant human HDAC7 (518 to 991 residues) expressed in insect cells using trifluoroacetyl lysine as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed