BDBM50591659 CHEMBL5196373

SMILES CN1CCN(CCOc2ccc(-c3c(sc4ncnc(O[C@H](Cc5ccccc5OCc5ccnn5CC(F)(F)F)C(O)=O)c34)-c3ccco3)c(C)c2Cl)CC1

InChI Key InChIKey=XDYLIYOOERYQTB-UHFFFAOYSA-N

Data  3 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591659   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: <1.20nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed