BDBM50591850 CHEMBL5184498

SMILES ONC(=O)c1ccc(CNC(=O)N2CCC(CC2)N2[C@@H]([C@H](C2=O)c2ccccc2)c2ccccc2)cc1

InChI Key InChIKey=XSEMMBSLRMCHPX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591850   

TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant human full length C-terminal FLAG/His-tagged HDAC1 expressed in Sf9 insect cells using ZMAL (Z-(Ac)Lys-AMC as substrate mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG tagged HDAC10 expressed in baculovirus infected Sf9 insect cells using fluorogenic substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed