BDBM50591875 CHEMBL5179613

SMILES CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)n1cc(nn1)-c1ccc(N)nc1

InChI Key InChIKey=RZHUMJSINYZTBK-KXBFYZLASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50591875   

TargetTyrosine-protein kinase ABL1 [T315I]/Breakpoint cluster region protein(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591875(CHEMBL5179613)
Affinity DataIC50:  125nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591875(CHEMBL5179613)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed